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1

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., Charpentier, E.

Journal:

Year:

2012

Language:

english

File:

PDF, 2.05 MB

english, 2012

2

An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3

Sashital, Dipali G, Jinek, Martin, Doudna, Jennifer A

Journal:

Nature Structural and Molecular Biology

Year:

2011

Language:

english

File:

PDF, 1.91 MB

english, 2011

3

Deciphering Off-Target Effects in CRISPR-Cas9 through Accelerated Molecular Dynamics

Ricci, Clarisse G., Chen, Janice S., Miao, Yinglong, Jinek, Martin, Doudna, Jennifer A., McCammon, J. Andrew, Palermo, Giulia

Journal:

ACS Central Science

Year:

2019

Language:

english

File:

PDF, 6.41 MB

english, 2019

4

A three-dimensional view of the molecular machinery of RNA interference

Jinek, Martin, Doudna, Jennifer A.

Journal:

Year:

2009

Language:

english

File:

PDF, 2.44 MB

english, 2009

5

DNA Interrogation by the CRISPR RNA-Guided Endonuclease Cas9

Sternberg, Samuel H., Redding, Sy, Jinek, Martin, Greene, Eric C., Doudna, Jennifer A.

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 40 KB

english, 2014

6

A prudent path forward for genomic engineering and germline gene modification

Baltimore, D., Berg, P., Botchan, M., Carroll, D., Charo, R. A., Church, G., Corn, J. E., Daley, G. Q., Doudna, J. A., Fenner, M., Greely, H. T., Jinek, M., Martin, G. S., Penhoet, E., Puck, J., Stern

Journal:

Year:

2015

Language:

english

File:

PDF, 267 KB

english, 2015

7

RNA-programmed genome editing in human cells

Jinek, Martin, East, Alexandra, Cheng, Aaron, Lin, Steven, Ma, Enbo, Doudna, Jennifer

Journal:

Year:

2013

Language:

english

File:

PDF, 298 KB

english, 2013

8

Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

Jinek, M., Jiang, F., Taylor, D. W., Sternberg, S. H., Kaya, E., Ma, E., Anders, C., Hauer, M., Zhou, K., Lin, S., Kaplan, M., Iavarone, A. T., Charpentier, E., Nogales, E., Doudna, J. A.

Journal:

Year:

2014

Language:

english

File:

PDF, 4.19 MB

english, 2014

9

CrispRVariants charts the mutation spectrum of genome engineering experiments

Lindsay, Helen, Burger, Alexa, Biyong, Berthin, Felker, Anastasia, Hess, Christopher, Zaugg, Jonas, Chiavacci, Elena, Anders, Carolin, Jinek, Martin, Mosimann, Christian, Robinson, Mark D

Journal:

Nature Biotechnology

Year:

2016

Language:

english

File:

PDF, 531 KB

english, 2016

10

Cas9 versus Cas12a/Cpf1: Structure-function comparisons and implications for genome editing

Swarts, Daan C., Jinek, Martin

Journal:

Wiley Interdisciplinary Reviews: RNA

Year:

2018

Language:

english

File:

PDF, 3.82 MB

english, 2018

11

Structural Basis for DNase Activity of a Conserved Protein Implicated in CRISPR-Mediated Genome Defense

Blake Wiedenheft, Kaihong Zhou, Martin Jinek, Scott M. Coyle, Wendy Ma, Jennifer A. Doudna

Journal:

Year:

2009

Language:

english

File:

PDF, 1.38 MB

english, 2009

12

Structural Biology of Nucleocytoplasmic Transport

Cook, Atlanta, Bono, Fulvia, Jinek, Martin, Conti, Elena

Journal:

Annual Review of Biochemistry

Year:

2007

Language:

english

File:

PDF, 1.32 MB

english, 2007

13

DNA interrogation by the CRISPR RNA-guided endonuclease Cas9

Sternberg, Samuel H., Redding, Sy, Jinek, Martin, Greene, Eric C., Doudna, Jennifer A.

Journal:

Year:

2014

Language:

english

File:

PDF, 6.80 MB

english, 2014

14

Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease

Haurwitz, R. E., Jinek, M., Wiedenheft, B., Zhou, K., Doudna, J. A.

Journal:

Year:

2010

Language:

english

File:

PDF, 1.14 MB

english, 2010

15

Foliage susceptibility of six eastern Canadian forest tree species to Phytophthora ramorum

Jinek, A., Simard, M., Brière, S. C., Watson, A. K., Tweddell, R. J., Rioux, D.

Journal:

Canadian Journal of Plant Pathology

Year:

2011

File:

PDF, 125 KB

2011

16

Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex

Clerici, Marcello, Faini, Marco, Muckenfuss, Lena M., Aebersold, Ruedi, Jinek, Martin

Journal:

Nature Structural and Molecular Biology

Year:

2018

Language:

english

File:

PDF, 1.30 MB

english, 2018

17

Key role of the REC lobe during CRISPR–Cas9 activation by ‘sensing’, ‘regulating’, and ‘locking’ the catalytic HNH domain

Palermo, Giulia, Chen, Janice S., Ricci, Clarisse G., Rivalta, Ivan, Jinek, Martin, Batista, Victor S., Doudna, Jennifer A., McCammon, J. Andrew

Journal:

Quarterly Reviews of Biophysics

Year:

2018

Language:

english

File:

PDF, 841 KB

english, 2018

18

Introducing gene deletions by mouse zygote electroporation of Cas12a/Cpf1

Dumeau, Charles-Etienne, Monfort, Asun, Kissling, Lucas, Swarts, Daan C., Jinek, Martin, Wutz, Anton

Journal:

Transgenic Research

Year:

2019

Language:

english

File:

PDF, 898 KB

english, 2019

19

Structures of the tRNA export factor in the nuclear and cytosolic states

Cook, Atlanta G., Fukuhara, Noemi, Jinek, Martin, Conti, Elena

Journal:

Year:

2009

Language:

english

File:

PDF, 1.36 MB

english, 2009

20

Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation

Jinek, Martin, Fabian, Marc R, Coyle, Scott M, Sonenberg, Nahum, Doudna, Jennifer A

Journal:

Nature Structural and Molecular Biology

Year:

2010

Language:

english

File:

PDF, 583 KB

english, 2010

21

Structural insights into the Notch-modifying glycosyltransferase Fringe

Jinek, Martin, Chen, Ya-Wen, Clausen, Henrik, Cohen, Stephen M, Conti, Elena

Journal:

Nature Structural and Molecular Biology

Year:

2006

Language:

english

File:

PDF, 233 KB

english, 2006

22

The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin α

Jínek, Martin, Rehwinkel, Jan, Lazarus, Brooke D, Izaurralde, Elisa, Hanover, John A, Conti, Elena

Journal:

Nature Structural and Molecular Biology

Year:

2004

Language:

english

File:

PDF, 1.49 MB

english, 2004

23

Development of a disease control programme based on the use of an inactivated vaccine against infectious bovine rhinotracheitis

Z. Pospíšil, J. Krejcí, P. Jínek, P. Lány, D. Zendulková, P. Cíhal

Journal:

Veterinary Microbiology

Year:

1996

Language:

english

File:

PDF, 702 KB

english, 1996

24

Use of RNA Tertiary Interaction Modules for the Crystallisation of the Spliceosomal snRNP Core Domain

Adelaine K.W. Leung, Christian Kambach, Yasushi Kondo, Martin Kampmann, Martin Jinek, Kiyoshi Nagai

Journal:

Journal of Molecular Biology

Year:

2010

Language:

english

File:

PDF, 1.19 MB

english, 2010

25

Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation

Marc R. Fabian, Géraldine Mathonnet, Thomas Sundermeier, Hansruedi Mathys, Jakob T. Zipprich, Yuri V. Svitkin, Fabiola Rivas, Martin Jinek, James Wohlschlegel, Jennifer A. Doudna, Chyi-Ying A. Chen, A

Journal:

Year:

2009

Language:

english

File:

PDF, 1.05 MB

english, 2009

26

Coupled 5′ Nucleotide Recognition and Processivity in Xrn1-Mediated mRNA Decay

Martin Jinek, Scott M. Coyle, Jennifer A. Doudna

Journal:

Year:

2011

Language:

english

File:

PDF, 1.14 MB

english, 2011

27

Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5

Kassube, Susanne A, Jinek, Martin, Fang, Jie, Tsutakawa, Susan, Nogales, Eva

Journal:

Nature Structural and Molecular Biology

Year:

2013

Language:

english

File:

PDF, 1.68 MB

english, 2013

28

Single-Molecule Observation of Viral DNA Targeting by CRISPR/Cas Immune Systems

Sternberg, Samuel H., Redding, Sy, Bhat, Prashant, Jinek, Martin, Wiedenheft, Blake, Doudna, Jennifer A., Greene, Eric C.

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 37 KB

english, 2013

29

History of European ideas special topic issues in print

Sternberg, Samuel H., Redding, Sy, Bhat, Prashant, Jinek, Martin, Wiedenheft, Blake, Doudna, Jennifer A., Greene, Eric C.

Journal:

History of European Ideas

Year:

1987

Language:

english

File:

PDF, 47 KB

english, 1987

30

Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

Anders, Carolin, Niewoehner, Ole, Duerst, Alessia, Jinek, Martin

Journal:

Year:

2014

Language:

english

File:

PDF, 4.69 MB

english, 2014

31

Structural and Biochemical Studies of a Fluoroacetyl-CoA-Specific Thioesterase Reveal a Molecular Basis for Fluorine Selectivity

Weeks, Amy M., Coyle, Scott M., Jinek, Martin, Doudna, Jennifer A., Chang, Michelle C. Y.

Journal:

Year:

2010

Language:

english

File:

PDF, 2.56 MB

english, 2010

32

The C-terminal region of Ge-1 presents conserved structural features required for P-body localization

Jinek, M., Eulalio, A., Lingel, A., Helms, S., Conti, E., Izaurralde, E.

Journal:

Year:

2008

Language:

english

File:

PDF, 652 KB

english, 2008

33

Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases

Niewoehner, O., Jinek, M., Doudna, J. A.

Journal:

Nucleic Acids Research

Year:

2014

Language:

english

File:

PDF, 8.57 MB

english, 2014

34

Structural basis for the endoribonuclease activity of the type III-A CRISPR-associated protein Csm6

Niewoehner, Ole, Jinek, Martin

Journal:

Year:

2016

Language:

english

File:

PDF, 1.68 MB

english, 2016

35

Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9

Anders, Carolin, Bargsten, Katja, Jinek, Martin

Journal:

Year:

2016

Language:

english

File:

PDF, 2.16 MB

english, 2016

36

Data-collection strategy for challenging native SAD phasing

Olieric, Vincent, Weinert, Tobias, Finke, Aaron D., Anders, Carolin, Li, Dianfan, Olieric, Natacha, Borca, Camelia N., Steinmetz, Michel O., Caffrey, Martin, Jinek, Martin, Wang, Meitian

Journal:

Acta Crystallographica Section D Structural Biology

Year:

2016

Language:

english

File:

PDF, 1.31 MB

english, 2016

37

Crystal structure of the C-terminal 2′,5′-phosphodiesterase domain of group a rotavirus protein VP3

Brandmann, Tobias, Jinek, Martin

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2015

Language:

english

File:

PDF, 529 KB

english, 2015

38

Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations

Palermo, Giulia, Miao, Yinglong, Walker, Ross C., Jinek, Martin, McCammon, J. Andrew

Journal:

ACS Central Science

Year:

2016

Language:

english

File:

PDF, 4.69 MB

english, 2016

39

Molecular basis for cytoplasmic RNA surveillance by uridylation‐triggered decay in Drosophila

Reimão‐Pinto, Madalena M, Manzenreither, Raphael A, Burkard, Thomas R, Sledz, Pawel, Jinek, Martin, Mechtler, Karl, Ameres, Stefan L

Journal:

The EMBO Journal

Year:

2016

Language:

english

File:

PDF, 7.26 MB

english, 2016

40

CRISPR-Cas9: Computational Insights Toward Improved Genome Editing

Palermo, Giulia, Miao, Yinglong, Walker, Ross C., Jinek, Martin, McCammon, J. Andrew

Journal:

Biophysical Journal

Year:

2017

Language:

english

File:

PDF, 40 KB

english, 2017

41

Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a

Swarts, Daan C., van der Oost, John, Jinek, Martin

Journal:

Year:

2017

Language:

english

File:

PDF, 4.41 MB

english, 2017

42

CRISPR-Cas9 conformational activation as elucidated from enhanced molecular simulations

Palermo, Giulia, Miao, Yinglong, Walker, Ross C., Jinek, Martin, McCammon, J. Andrew

Journal:

Proceedings of the National Academy of Sciences

Year:

2017

Language:

english

File:

PDF, 1.64 MB

english, 2017

43

Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers

Niewoehner, Ole, Garcia-Doval, Carmela, Rostøl, Jakob T., Berk, Christian, Schwede, Frank, Bigler, Laurent, Hall, Jonathan, Marraffini, Luciano A., Jinek, Martin

Journal:

Year:

2017

Language:

english

File:

PDF, 6.37 MB

english, 2017

44

PAM-induced allostery activates CRISPR-Cas9

Palermo, Giulia, G. Ricci, Clarisse, Fernando, Amendra, Basak, Rajshekhar, Jinek, Martin, Rivalta, Ivan, Batista, Victor S., McCammon, J. Andrew

Journal:

Journal of the American Chemical Society

Year:

2017

Language:

english

File:

PDF, 879 KB

english, 2017

45

Specialized Weaponry: How a Type III-A CRISPR-Cas System Excels at Combating Phages

Niewoehner, Ole, Jinek, Martin

Journal:

Cell Host & Microbe

Year:

2017

Language:

english

File:

PDF, 172 KB

english, 2017

46

Molecular architectures and mechanisms of Class 2 CRISPR-associated nucleases

Garcia-Doval, Carmela, Jinek, Martin

Journal:

Current Opinion in Structural Biology

Year:

2017

Language:

english

File:

PDF, 2.86 MB

english, 2017

47

Bacteriophage DNA glucosylation impairs target DNA binding by type I and II but not by type V CRISPR–Cas effector complexes

Vlot, Marnix, Houkes, Joep, Lochs, Silke J.A., Swarts, Daan C., Zheng, Peiyuan, Kunne, Tim, Mohanraju, Prarthana, Anders, Carolin, Jinek, Martin, van der Oost, John, Dickman, Mark J., Brouns, Stan J.J

Journal:

Nucleic Acids Research

Year:

2017

Language:

english

File:

PDF, 3.25 MB

english, 2017

48

Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes

Brandmann, Tobias, Fakim, Hana, Padamsi, Zoya, Youn, Ji‐Young, Gingras, Anne‐Claude, Fabian, Marc R, Jinek, Martin

Journal:

The EMBO Journal

Year:

2018

Language:

english

File:

PDF, 1.42 MB

english, 2018

49

Author Correction: Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex

Clerici, Marcello, Faini, Marco, Muckenfuss, Lena M., Aebersold, Ruedi, Jinek, Martin

Journal:

Nature Structural and Molecular Biology

Year:

2018

File:

PDF, 528 KB

2018

50

Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex

Clerici, Marcello, Faini, Marco, Aebersold, Ruedi, Jinek, Martin

Journal:

Year:

2017

Language:

english

File:

PDF, 1.45 MB

english, 2017

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